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General / Hypothyroidism/Hashi - Help for low Ferritin! notify me whenever anyone posts in this discussionSubscribe

From: Debra (momma110) Mar-25 12:54 am
To: Deborah7 (Deborah10316) (14 of 27)
66235.14 in reply to 66235.11

Here are some excerpts from articles I think you might find interesting. They explain how the low iron/ferritin condition may be making you feel hyper when you try to take an appropriate dose of thyroid med; and other correlations of iron/ferritin and thyroid status.
"The following study sheds light on the situation faced when the patient cannot tolerate taking thyroid replacement hormone. The person experiences rapid heart beat and palpitations. This indicates that the person is probably anemic from iron deficiency and will tolerate thyroxin when the anemia is corrected. "

Mayo Clin Proc 2000 Feb;75(2):189-92

Anemia: a cause of intolerance to thyroxine sodium.

Shakir KM, Turton D, Aprill BS, Drake AJ 3rd, Eisold JF

Department of Internal Medicine, National Naval Medical Center, Bethesda, Md., 20889-5600, USA.

Usual causes of intolerance to thyroxine sodium include coronary artery disease, advanced age, untreated adrenal insufficiency, and severe hypothyroidism. We describe 4 patients with iron deficiency anemia and primary hypothyroidism. After treatment with thyroxine sodium, these patients developed palpitations and feelings of restlessness, which necessitated discontinuation of the thyroid hormone. After the anemia was treated with ferrous sulfate for 4 to 7 weeks, they were able to tolerate thyroxine sodium therapy. Iron deficiency anemia coexisting with primary hypothyroidism results in a hyperadrenergic state. In such patients, we postulate that thyroid hormone administration causes palpitations, nervousness, and feelings of restlessness. Correction of any existing pronounced anemia in hypothyroid patients who are intolerant to thyroxine sodium therapy may result in tolerance to this agent.
http://www.ithyroid.com/iron.htm

"Serum ferritin as a marker of thyroid hormone action on peripheral tissues

J Takamatsu, M Majima, K Miki, K Kuma and T Mozai

Serum ferritin measurements were evaluated as a marker of thyroid hormone action on peripheral tissues. Mean serum ferritin concentrations were not significantly different in euthyroid, thyrotoxic, and hypothyroid subjects due to a wide spread in ferritin levels among individuals. Intraindividual changes in serum ferritin, however, occurred with changing thyroid function. All 18 patients with thyrotoxic Graves' disease had a decrease in serum ferritin levels when they became euthyroid during antithyroid drug therapy. Furthermore, a significant intraindividual correlation between serum levels of ferritin and T4 or T3 was found in 2 patients with thyrotoxic Graves' disease in whom levels were measured serially throughout the course of therapy. Similarly, serum ferritin levels increased in all 12 hypothyroid patients with Hashimoto's disease when euthyroidism was achieved with L-T4 therapy. Administration of 75 micrograms T3 daily for 1 week to 11 euthyroid subjects resulted in a 23-243% (mean +/- SD, 117 +/- 70%) increase in serum ferritin above basal values. In contrast, in 3 patients with thyroid hormone resistance, the same treatment produced rises in serum ferritin concentrations of only 2%, 5%, and 15%. Our data suggest that alterations in thyroid status in a given individual produce changes in serum ferritin levels. Measurement of this protein before and after T3 therapy may prove useful in the diagnosis of thyroid hormone resistance. " http://jcem.endojournals.org/cgi/con...tract/61/4/672

Iron supplements benefit non-anaemic women with fatigue http://bmj.bmjjournals.com/cgi/conte...7399/1124?etoc
The following study indicates that iron helps to reduce goiter size. This is excellent evidence that iron is critical for thyroid function and that iron-deficiency anemia is often an important factor in causing hypothyroidism.
Eur J Endocrinol 2000 Mar;142(3):217-223
Iron supplementation in goitrous, iron-deficient children improves their response to oral iodized oil.
Zimmermann M, Adou P, Torresani T, Zeder C, Hurrell R. http://www.ithyroid.com/iron.htm
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Og den beste:
http://www.ncbi.nlm.nih.gov/entrez/q..._uids=10683660
Mayo Clin Proc. 2000 Feb;75(2):189-92. Related Articles, Links

Anemia: a cause of intolerance to thyroxine sodium.

Shakir KM, Turton D, Aprill BS, Drake AJ 3rd, Eisold JF.

Department of Internal Medicine, National Naval Medical Center, Bethesda, Md., 20889-5600, USA.

Usual causes of intolerance to thyroxine sodium include coronary artery disease, advanced age, untreated adrenal insufficiency, and severe hypothyroidism. We describe 4 patients with iron deficiency anemia and primary hypothyroidism. After treatment with thyroxine sodium, these patients developed palpitations and feelings of restlessness, which necessitated discontinuation of the thyroid hormone. After the anemia was treated with ferrous sulfate for 4 to 7 weeks, they were able to tolerate thyroxine sodium therapy. Iron deficiency anemia coexisting with primary hypothyroidism results in a hyperadrenergic state. In such patients, we postulate that thyroid hormone administration causes palpitations, nervousness, and feelings of restlessness. Correction of any existing pronounced anemia in hypothyroid patients who are intolerant to thyroxine sodium therapy may result in tolerance to this agent.

Publication Types:

* Case Reports


PMID: 10683660 [PubMed - indexed for MEDLINE]
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nora