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Tråd: T2 - 3,5-diiodothyronine
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06-12-09, 13:09 #3
Sv: T2 - 3,5-diiodothyronine
hehe det var nok ikke navnet på rottene...
Her er mer om rottene, fra pdf-en: "Male Wistar rats (Charles-Rivers, Lecco, Italy) weighing 270±300 g were used in this study."
Her fra konklusjonen:
"The results presented in this paper may help to answer another question about the physiological meaning of the effect exerted by 3,5-T2. An increased activity of the c-reducer and c-oxidizer blocks causes the increase in the mitochondrial respiration rate observed in the 3,5-T2 group. In the whole animal, this phenomenon may result in an increased metabolic rate. Because of this, the effect of 3,5-T2 could be important in certain physiological conditions in which rapid energy utilization is required (such as cold exposure, overfeeding, etc.). The effect of 3,5-T2 in improving the cold tolerance of hypothyroid rats supports this hypothesis [19].
3,5-T2, originating from precursor molecules (thyroxine and 3«,3,5-tri-iodo-l-thyronine) through peripheral metabolism, may be a cellular mediator for the short-term effect of thyroid hormones on cellular energetic metabolism, an effect that is independent of protein synthesis [15,27]. The presence of speci®c binding sites for 3,5-T2 in rat liver mitochondria would seem to support this hypothesis [16]."
Kroppen har altså reseptorer for t2. Dat betyr det er et hormon. (som kjent har kroppen ikke reseptorer for t4...)


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