Forskning i jod av dr. Sebastiano Venturi

[Mod]

Audiological and neuropsychological development study in a sample of school children from a low-iodine area of the Central Apennines that is endemic for cretinism.

Audiological and neuropsychological development study in a sample of school children from a low-iodine area of the Central Apennines that is endemic for cretinism
Donati L, Venturi S, Andreani M, Antonelli A, Gori E, Bertoni F, Pruneti CA, Berrettini S, Bruschini P, Baschieri L.
Minerva Endocrinologica Aprile-Giugno 1989, pagina 99-103
Article in Italian

Abstract. Neuropsychological and audiological study in "normal" schoolchildren in an iodine deficiency area with endemic cretinism in Central Apennines.

We have evaluated neuropsychic development in 70 normal schoolchildren in an area of severe endemic goitre and cretinism in Central Apennines (Montefeltro). In each subject we have studied auxological, psychometric and audiometric parameters, togehther with tympanogram and stapedial reflexogram. Auxological data were in the normal range, as stapedial reflexogram and tympanogram.

On the contrary, 54,8% of the sample performed below the 25th percentile in psychometric tests (Raven test PM-47), being also 22,8% below the 5th percentile. Audiometric data showed a neurological hearing impairment in 3,1% of the children tested, as compared with 0,28% in the area of Pisa. These data point out that an impairment of central nervous system function still persist in this area of severe endemic goitre. [Min Endocr 1989;14:99-103].

Key words: Endemic goitre, Neurological hypoacisua, Neuropsychic deficiency

Read more / Les mer... (in Italian) (PDF redirect Sites.google.com)


An iodine-deficient area with endemic cretinism in the Central Apennines: studies of neuropsychological development in schoolchildren.
Donati L, Venturi S, Andreani M, et al.
Journal of Endocrinological Investigation, 1988, 4 :11-12. nad IDD Newsletter, 1988

Will be updated. Not found yet...

[Mod]

Humoral thyroid autoimmunity is not involved in the pathogenesis of myxedematous endemic cretinism.

Humoral thyroid autoimmunity is not involved in the pathogenesis of myxedematous endemic cretinism.
L Chiovato, P Vitti, G Bendinelli, F Santini, E Fiore, M Tonacchera, C Mammoli, A Capaccioli, S Venturi, and E Pretell
J Clin Endocrinol Metab. 1995 May;80(5):1509-14.
DOI: http://dx.doi.org/10.1210/jcem.80.5.7744994

Abstract. A role of thyroid autoimmunity in the pathogenesis of myxedematous endemic cretinism was suggested by reports indicating the presence of thyroid growth-blocking antibodies in the sera of these patients. To check this hypothesis, we searched for TSH receptor antibodies with thyroid growth-blocking or adenylate cyclase (AC)-inhibiting (TSH-blocking) activity in immunoglobulin G (IgG) from 18 euthyroid and 21 hypothyroid endemic cretins living in Italy and Peru. Among hypothyroid cretins, 12 had no palpable goiter.

Stages I-III goiters were present in 12 of 18 euthyroid cretins. Controls included 25 euthyroid nongoitrous subjects living in the same endemic regions as cretins, and 10 normal subjects from an iodine-sufficient area. IgG from 4 selected patients with autoimmune atrophic thyroiditis and from 2 neonates with sporadic transient congenital hypothyroidism due to maternal TSH-blocking antibodies were included in the study.

The blocking effect of the IgG was assessed in FRTL-5 cells by measuring TSH-stimulated [3H]thymidine incorporation, DNA accumulation, and AC activation. A radioreceptor assay was used to detect TSH-binding inhibiting antibodies (TBIAb). No IgG from hypothyroid endemic cretins without goiter contained TBIAb or inhibited TSH-stimulated cell growth or AC activation. The effect of IgG from hypothyroid nongoitrous cretins did not differ from that produced by IgG from hypothyroid cretins with goiter, euthyroid cretins with or without goiter, or normal controls.

In contrast to these results, IgG from patients with autoimmune atrophic thyroiditis and from neonates with sporadic transient congenital hypothyroidism contained TBIAb that inhibited both TSH-stimulated cell growth and AC activation. In conclusion, our results indicate that, similar to other types of endemic cretinism, hypothyroid endemic cretins without goiter do not have TSH receptor antibodies able to inhibit TSH-stimulated thyroid cell growth or function.

These observations argue against a role of humoral thyroid autoimmunity in the development of myxedematous endemic cretinism.

Source: Press.endocrine.org

[Mod]

Extrathyroid Iodine Deficiency Disorders. What is the real iodine requirement?

I disordini extra-tiroidei da carenza iodica. Qual e il real fabbisogno di iodio?
(Extrathyroid Iodine Deficiency Disorders. What is the real iodine requirement?):
The Journal of Italian Society of Pharmacology (Le Basi Razioneali Della Terapia), 1996; 16: 267-75.

The authors report a recent review of the most important extrathyroid iodine deficiency disorders in relation to: stomach, immune system, mammary glands, ovaries, arterial and articular system, epidermis and nervous system. All these organs concentrate about 80% of total body iodine in humans and animals, but the role of this extrathyroid iodine is not known.

The hypothesis is that this iodine might have a specific antioxydant role, from primitive algae, which contain the highest level of iodine, and which were the first living cells to produce oxygen. So we believe that this phylogenetically ancient antioxydant role is important also in animals and humans. In fact, the thyroid gland is only a phylogenetically modern organ, which was improved from primitive Chordates to more recent Mammalia. In the references are reported different studies on the antioxydant ability of iodine in rates and in humans.

By Venturi S, Guidi A, Venturi M. in the Journal of Italian Society of Pharmacology (Le Basi Razioneali Della Terapia), 1996; 16: 267-75. (Source: Tulane University at Web.Archive.org)

[Mod]

Enigma of the function of iodide in primitive algae and in animal extrathyroidal organs: is it an ancient antioxidant?

Enigma of the function of iodide in primitive algae and in animal extrathyroidal organs: is it an ancient antioxidant?

Letter to the Editor

Dear Sir,
in relation to the functional role of inorganic iodide in metabolism of algal and animal cells, we have hypothesized, in previous (1) and recent works (2)(3) that iodide might have a (phylogenetically and evolutionistically) ancient antioxidant role in extrathyroidal iodide-concentrating cells.

Into these cells iodide may act as an electron donor in the presence of H2O2 and peroxidase, and the remaining iodine readily iodinates the tyrosine (and more slowly, the histidine (4)(5) or some protein and lipid), and so, neutralizes its own high oxidant power (3). In fact, three billion years ago, Algae, which contain a high amount of iodine, were the first living cells to produce oxygen, toxic at that time, in terrestrial atmosphere. So, algae cells required a protective antioxidant action in which iodides might have had a specific role.

Now this hypothesis of the antioxidant role of iodide is experimentally confirmed in Algae by a recent study carried out by Kupper et al. (6).

We believe that this work, which convalidates our hypothesis, may constitute a fundamental experimental milestone in the study of the extrathyroidal nonhormonal action of iodine-iodide in biology and physiology of the cells.

Several extrathyroidal organs in animals, many of which share the same gene expression of sodium-iodide symporter of thyroidal iodide-pump (7), particularly stomach mucosa and lactanting mammary gland, but also salivary glands, thymus, epidermis, choroid plexus, articular and arterial sistems, have a iodide-concentrating ability without showing any hormonal or biological action (8), and so, Algae, Porifera, Anthozoa (9) and several marine Invertebrates. In human organism extrathyroidal nonhormonal inorganic iodide is about 50-80% of the total amount of iodine and its role is not known. Besides, direct uptake of inorganic iodine by tumor shows experimentally a suppressive effect on DMBA-induced breast tumors growth in the rat (10). The antioxidant action of iodide may give a satisfactory explanation of the function of this trace-element and might be a very important knowledge for preventive purpose.

We should point out that extrathyroidal action of iodide might be an important new area for investigation.

REFERENCES

1. Venturi S et al (1993) A new hypothesis: iodine and gastric cancer. European Journal of Cancer Prevention. 2 :17-23
2. Venturi S & Venturi M (1998) Does iodine in the gastric mucosa have an ancient antioxidant role? IDD-Newsletter 14, 4 :61-2
3. Venturi S & Venturi M (1999). Iodide, thyroid and stomach carcinogenesis: evolutionary story of a primitive antioxidant? European Journal of Endocrinology 140, 4 :371-2
4. Li CH (1945) J Am Chem Soc 67 :1065
5. Mayberry WE & Hockert TJ (1970). Endocrinology 86 :225..
6. Kupper FC, Schweigert N, Ar Gall E, Legendre J-M, Vilter H & Kloareg B (1998). Iodine uptake in Laminariales involves extracellular, haloperoxidase-mediated oxidation of iodide. PLANCTA 207 :163-171
7. Spitzweg C, Joba W, Eisenmenger W & Heufelder AE (1998). Analysis of human sodium iodide symporter gene expression in extrathyroidal tissues and cloning of its complementary deoxyribonucleic acid from salivary gland, mammary gland, and gastric mucosa. J Clin Endocrinol Metab 83, 5 :1746-51
8. Venturi S, Guidi A & Venturi M (1996). I disordini extra-tiroidei da carenza iodica. Qual è il reale fabbisogno di iodio? Le Basi Razionali della Terapia 16 :267-75
9. Roche J (1952) Biochimie comparée des scléroprotéines iodées des Anthozoaires et des Spongiaires. Experientia 8 :45-56
10. Funahashi H, Imai T, Tanaka Y, Tobinaga J, Wada M, Morita T & al. (1996) Suppressive effect of iodine on DMBA-induced breast tumor growth in the rat. J Surg Oncol 61, 3 :209-13

[Mod]

Preliminary study on the relation between alimentary iodine deficiency and gastric cancer: specific prevention prospects

Preliminary study on the relation between alimentary iodine deficiency and gastric cancer: specific prevention prospects
Book in Italian with summary in English
By S. VENTURI, Pennabilli, Italy. 1-9-1985.

This book has the following stated objective: "correlation between alimentary iodine deficiency and gastric cancer".
The 3 methods employed are:

1) Epidemiological Studies
2) Study of the relation between iodine deficiency and lack of immune defense, by Skin-test
3) Relation between gastric and Thyroid diseases
Summary
Competitors anions contents: Specific prevention prospects.

See image