Nye skjoldbrukskjertler av stamceller? (English)

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Thyroid regeneration: how stem cells play a role?
Front. Endocrinol., 14 April 2014 | doi: 10.3389/fendo.2014.00055

Conclusion. We have begun understanding the nature of adult thyroid stem/progenitor cells and possible mechanisms of their involvement in thyroid regeneration when thyroid is damaged and requires repair. At least two models for thyroid repair are proposed involving different types of stem/progenitor cells; one for mature cells reprogramed back to immature endoderm lineage-committed progenitor cells, and the other involving cells that appear to be adult-resident stem/progenitor cells. Processes required for tissue repair may have many similarities to cancer development and metastasis, or may provide insight into the development of various other thyroid diseases. Understanding normal adult thyroid stem/progenitor cells and their involvement in thyroid repair should help better understand these diseases, hopefully leading to better diagnosis and/or treatment.

Source / Read more: Journal.frontiersin.org

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Researchers Create Thyroid Cells From Human Stem Cells

"We've shown very clearly that by pushing human embryonic stem cells into thyroid cells, these cells form follicles, and they function," Davies said. "They take up radioiodine and look like normal thyroid cells."

"What's interesting is that while putting transcription factors into human embryonic stem cells does start the program, those cells don't make thyroglobulin," Davies said. "They show a very little bit of thyroglobulin mRNA, but we've not been able to detect protein in those cells. We have to mature the cell further."

To do that, Davies and his team exposed the cells to activin A, moving them into a different differentiation phase in which they transformed into endodermal cells. The final step is to "hit them with thyroid stimulating hormone," Davies said.

"That activates the TSH receptor and takes them through to make thyroid follicles," he said. "Those thyroid follicles express lots of thyroglobulin and lots of thyroid peroxidase, and they take up radioiodine. So they seem to be good-looking thyroid follicles."

Source / Read more: Medpagetoday.com

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World's first 3D-bioprinted transplant-ready thyroid gland to be unveiled in early 2015

The first living organ, created with the use of 3D-bioprinter, will be released next year, Russian scientists announced. The experiment will start with a transplant-ready thyroid, with further work on a functional printed kidney scheduled for 2018.

The researchers from "3D Bioprinting Solutions" laboratory at the Skolkovo innovation center outside Moscow have set an exact date for the first three-dimensional organ to be bioprinted, saying the result of the "revolutionary" technology will be unveiled on March 15 next year.

The first organ to be created with a bioprinter, using stem cells as an 'ink', will be a thyroid gland. This body part has been chosen to launch the experiment for its "simplicity," according to the laboratory head of research, Vladimir Mironov. The professor hopes the thyroid will also be apparent in proving bioprinted organs compatibility with living organisms.

Source / Read more: Bioprinted Organ Transplant and...
Bioprinted Thyroid Gland by 2015, Kidney by 2018, Says Russian Scientists

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Thyroid stem cells – danger or resource? (PDF)
Acta Otorhinolaryngol Ital 2009;29:290-295

Denne tråden vil bli oppdatert...

[Mod]

World's first 3D-bioprinted transplant-ready thyroid gland to be unveiled in early 2015

The first living organ, created with the use of 3D-bioprinter, will be released next year, Russian scientists announced. The experiment will start with a transplant-ready thyroid, with further work on a functional printed kidney scheduled for 2018.

The researchers from "3D Bioprinting Solutions" laboratory at the Skolkovo innovation center outside Moscow have set an exact date for the first three-dimensional organ to be bioprinted, saying the result of the "revolutionary" technology will be unveiled on March 15 next year.

The first organ to be created with a bioprinter, using stem cells as an 'ink', will be a thyroid gland. This body part has been chosen to launch the experiment for its "simplicity," according to the laboratory head of research, Vladimir Mironov. The professor hopes the thyroid will also be apparent in proving bioprinted organs compatibility with living organisms.

Source / Read more: Bioprinted Organ Transplant and...
Bioprinted Thyroid Gland by 2015, Kidney by 2018, Says Russian Scientists

Snart kan vi lage levende organer med 3-D-printer

Russere vil printe skjoldbruskkjertel i år

"Mange eksperter advarer om at det vil vise seg ekstremt vanskelig å printe levedyktige erstatningsorganer, særlig når det gjelder så komplekse organer som hjernen. Dessuten er det vanskelig å printe nettverket av blodkar som behøves for å forsyne organer med oksygen og næringsstoffer.

Ikke desto mindre sier forskere ved universitetet i Pennsylvania at de har funnet en måte å trykke slike nettverk, og et russisk selskap, 3-D Bioprinting Solutions, har lovet at de i år skal printe en skjoldbruskkjertel, som er snørt sammen av blodkar. Andre forskere er i ferd med å printe vev til bukspyttkjertelen som kan hjelpe til med å kontrollere diabetes, virus som angriper kreftceller og organmodeller som kirurgene kan øve seg på eller som kan brukes til å lage medisinske apparater."

Les mer i Aftenposten Oppdatert: 21.mar. 2015 21:25