Endokrinologer halverte behandlingsdoser i 1973

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Jeg har lest på www.drlowe.com at amerikanske endokrinologer halverte behandlingsdosene med tyroksin i 1973.

Dessverre er Dr Lowes nettinfo ikke lenger tilgjengelig

"The number of patients with chronic, widespread pain (a classic symptom of hypothyroidism) increased in the mid-1970s to a point that rheumatologists began totake notice. This occurred shortly after endocrinologists, in 1973 and 1974, recommended cutting hypothyroid patients’ thyroid hormone dosages in half. This reduced patients’ dosages from the equivalent of 200-to-400 mcg of T4 to 100-to-200 mcg. [74][75] The purpose was to raise the patients’ TSH levels. (The new TSH test had recently come into widespread use.)" (...)

"As standard practice at this time, physicians had come to adjust patients’ thyroid hormone dosages to keep their TSH levels within the reference range.[77] As Dr. David Derry wrote in the British Medical Journal, "In 1973 thyroidologists officially endorsed the newly designed TSH test for thyroid function . . . ."[78]

• [74] Evered, D., Young, E.T., Ormston, B.J., et al.: Treatment of hypothyroidism: a reappraisal of thyroxine therapy. Br Med J. Jul 21, 1973; 3(5872): 131–134.
• [75] Stock, J.M., Surks, M.I., and Oppenheimer, J.H.: Replacement dosage of L-thyroxine in hypothyoidism - A Re-Evaluation N. Engl. J. Med., 1974 Mar 7;290(10):529–533.
• [77] Vanderpump, M.P., Ahlquist, J.A., Franklyn, J.A., et al.: Consensus statement for good practice and audit measures in the management of hypothyroidism and hyperthyroidism. The Research Unit of the Royal College of Physicians of London, the Endocrinology and Diabetes Committee of the Royal College of Physicians of London, and the Society for Endocrinology. BMJ. Aug 31, 1996; 313(7056): 539–544.
• [78] Derry, D.M.: Consequences of the TSH. BMJ 2000;320:1332

Source/Kilde: Critique of replacement studies by Dr. J. C. Lowe