Flere enn Hertoge som lovpriser veksthormon?

[Anisa]

Min IGF-1 er målt i forbindelse med en standard prøvepakke som taes i forbindelse med synachten test. Selvsagt måles ikke veksthormon i seg selv, fordi den eneste årsaken til at man har høy IGF-1 i legenes øyne er forhøyet mengde veksthormon. Jeg spør meg selv om det er tilfelle? Og i tillegg er den ikke høy nok til at den skal være sykdomsfremkallende. Hadde noe høy SHBG som var tatt samtidig, men det hang nok sammen med for høy dose thyroid. Er på en dose som jeg føler passer meg bedre nå.

Hej Blondie Hvis dit IGF fortsat spræller... kan du måske bruge den artikel jeg tilfældigvis fandt i dag, mens jeg ledte efter noget lidt andet. En "friskbagt" fra januar i år:

Context: Measurement of IGFBP-3 can aid the diagnosis of growth hormone related diseases. Furthermore, epidemiological studies suggest that IGFBP-3 and the molar IGF-I/IGFBP-3 ratio are associated with clinical endpoints like cancer or cardiovascular disease. However, their clinical use is limited by the lack of validated reference intervals.

Objectives: Establishment of age- and sex-specific reference intervals for IGFBP-3 and the molar IGF-I/IGFBP-3 ratio by newly developed automated immunoassays.

Setting: Multicentre study with samples from 11 cohorts from the USA, Canada and Europe Participants: 14,970 subjects healthy subjects covering all ages from birth to senescence. Main outcome measures: Concentrations of IGFBP-3 and the IGF-I/IGFBP-3 ratio as determined by the IDS iSYS IGF-I and IGFBP-3 assays.

Results: Both the concentration of IGFBP-3 and the IGF-I/IGFBP-3 ratio are mainly determined by age. IGFBP-3 concentrations increase until the age of 22 years, with a plateau being visible between 15 and 25 years. Determined by the high peripubertal peak in IGF-I, the peak in the IGF-I/IGFBP-3 ratio occurs already around the age of 15, with a slightly earlier and higher peak in females. Beyond the age of 60, IGFBP-3 concentrations remain higher in females, whereas IGF-I as well as the IGF-I/IGFBP-3 ratio remain significantly higher in males.

Conclusions: We present an extensive set of assay specific, age and sex-adjusted normative data for concentrations of IGFBP-3 and the molar IGF-I/IGFBP-3 ratio and demonstrate distinct sex specific differences across lifespan.

Kilde: Age and sex specific reference intervals across life-span for insulin-like growth factor binding protein 3 (IGFBP-3) and the IGF-I/IGFBP-3 ratio measured by new automated chemiluminescence assays.