No but it is unusual to have a mitochondrial issue. The usual problem is lack of glucose flow into the cells which can be tested with a glucose tolerance test (GTT) and insulin testing during the GTT.

Also it is important to be on supplements to ensure no vitamins or minerals that are co-factors within the cells for the key processes are not deficient. The usual supplements I suggest are:

B complex (50mg of B1-B6) - twice a day with food.
B12 - 500mcg-1000mcg - once a day with food.
C - 500mg four to six times a day - with or without food
D3 - 2500 - 5000 IUS a day - once a day if no kidney problems (higher if low)
a chelated multi-mineral - once a day with food
200-400mg chelated magnesium (has to be chelated) - twice a day with food.