Diiodothyronine (T2) og Monoiodothyronine (T1)

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Jeg har prøvd å søke på T1 og T2...

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Monoiodothyronine
Monoiodothyronine is an iodothyronine metabolite. It has unknown physiological functions.

PubChem ID: 123785
Structure (SMILES): C1=CC(=CC=C1O)OC2=C(C=C(C=C2)CC(C(=O)O)N)I
Also known as: 3-Iodothyronine, 3-T1, O-(4-Hydroxyphenyl)-3-iodotyrosine, iodo-Thyronine
Metabocard for Monoiodothyronine

Diiodothyronine
Until recent years, Diiodothyronine (T2) was considered an inactive metabolite of thyroid hormones thyroxine (T4) and triiodo-L-thyronine (T3). Early studies dealing with the biological activities of this iodothyronine revealed its ability to stimulate cellular/mitochondrial respiration, essentially by a nuclear-independent pathway. Mitochondria and the energytransduction apparatus seem to be major targets of T2, although outside the mitochondria T2 also has effects on carriers, ion-exchangers and enzymes. Recent studies suggest that T 2 may also affect the transcription of some genes, but again the underlying mechanisms seem to differ from those actuated by T3. The accumulated evidence permits the conclusion that the actions of T2 do not simply mimic those of T3 but instead are specific actions exerted through mechanisms that are independent of those actuated by T3 and do not involve thyroid hormone receptors. In addition, very recent evidence leads us to suggest that T2 may be a potentially useful agent for the treatment of diet-dependent overweight (and the consequent hypertriglyceridemia and high cholesterol level) without inducing thyrotoxicosis. (Medical Hypotheses (1988), 27(4), 303-11.)

PubChem ID: 123675
Formula: C15H13I2NO4
Structure (SMILES): C1=CC(=CC=C1O)OC2=C(C=C(C=C2I)CC(C(=O)O)N)I
Also known as: 3,5-Diiodo-L-thyronine, 3-[4-(p-hydroxyphenoxy)-3,5-diiodophenyl]-L-Alanine, Diiodo-L-thyronine, L-3,5-Diiodothyronine, L-Diiodothyronine, L-T2, O-(4-Hydroxyphenyl)-3,5-diiodo-L-tyrosine, l-o-(4-hydroxyphenyl)-3,5-diiodo-tyrosine
Metabocard for Diiodothyronine