Open Letter to Mark Vanderpump

[smgj]

Jeg hadde ikke en anelse om at så lite av de hormonene vi har i blodet faktisk er frie... i forhold til proteinbundede. Med syntetiske tilskudd må da kroppen gå og kjempe imot en tilstand av "kronisk overdosering" ... Ikke rart at det går feil og at omdanningen til fT3 for mange strupes i stedet for å normaliseres.

Det fremsetter jo også implisitt hvorfor at fT3-produkter "ikke fungerer" og må deles i mikroskopiske doser og pulsdoseres for å gi en brukbar virkning...

Jeg har forøvrig en kollega, en mann i begynnelsen av 60årene som har fått konstatert stoffskiftesykdom (en tidligere meget aktiv mann) ... som nå er "velregulert", men har gått fra å komme tilbake i jobb, ned i 50% og nå ut i full sykemelding. Legen mener det må være utbrenthet, fordi stoffskiftet er som kjent; "velregulert".

Har sendt et par artikler og snakket litt, men "man kan leie hesten til krybba, men ikke tvinge ham til å spise". Jeg håper at frøet jeg har sådd vil spire, men har ikke høye håp. Er redd for at hans yrkeskarriere er over.

Som jeg har sagt før... det er lett å kjøre over pasienter som ikke har overskudd og kognitive evner til å protestere lenger... og med standardbehandlingen så gjelder dessverre det mange.

Ops – I realized that this is supposed to be an English only-thread, so I will supply a translation of my small rant above:

I had no idea that so little of the thyroid hormones in serum was "free" compared to being protein bound. On synthetic fT4 substitution, the body probably will have to fight all the signs of being chronically overdosed.

No wonder that the treatment is less than successful for many sufferers, and that the result is poor conversion from fT4 to fT3.
The article also hints at why synthetic fT3 substitution is so poorly tolerated by most and why it most often need a rigorously pulse dose regime to be successful.

I have a colleague, a man in his early sixties, diagnosed with low thyroid (he has always enjoyed actively biking the nearly ten years I have known the man). The doctor says the thyroid is "well regulated", but the man has gone from "getting back at work", "down to 50%" and now into "full sick leave". The doctor says it has to be "long time stress/ he has to be burnt out" … because it can't possibly be the thyroid since it is "well regulated" on fT4 substitution.

I've mailed him a couple of articles and talked a bit, but there is a Norwegian saying that "you can lead the horse to its trough but you can't force it to drink". I hope that the seed I have sown will germinate, but I do not have high hope. I am afraid that (he will continue to trust that his doctor knows best and that) his working career is over.

As I have said earlier as well. It is all too easy to run over patients with no physical or cognitive reserve left. With today's standard treatment regime, many will unfortunately meet that faith.