Hvorfor er den viktigste faktoren som kan forutsi kroniske sykdommer traumer i barndommen?

ACE er navnet på en stor undersøkelse. ACE står for Adverse Childhood Experiences, eller alvorlige erfaringer i barndommen på norsk.
http://www.nicabm.com/trauma-and-chr...e/1/confirmed/
www.ACEStudy.org
Her finnes flere av publikasjonene til undersøkelsen http://www.acestudy.org/download

Noen utdrag av det de fant:
En skremmende lenke mellom barndomstraumer og 20 år kortere forventet levetid
Svar på hvorfor handlingsmønstre til traumeoverlevere ofte øker og blir mer komplekse
Mulighetene for å få kroniske sykdommer øker
Samband mellom traumer og hjertesykdom
En lenke mellom barndomstraumer og betennelser (her er det også snakk om mange autoimmune sykdommer)

When a monumental study connects two previously unrelated factors and puts them together with astounding results, the implications are too compelling to ignore.
Almost by accident, this is exactly what happened in a study that began in the early 1990s.
Taking two fundamental factors of mind-body medicine, childhood trauma and chronic disease, two physicians, Vincent Felitti, MD along with Robert Anda, MD designed a study based on a clinical hunch.
Noticing that so many of their patients presented with symptoms of chronic disease, they also observed that these same patients were very often survivors of multiple and repeated childhood traumas.
Could there be a link between childhood trauma and chronic disease?
....Analyzing the relationship between multiple categories of childhood trauma and health outcomes later in life, researchers defined nine Adverse Childhood Experiences that can occur in the household prior to age 18:

Recurrent physical abuse
Recurrent emotional abuse
Contact sexual abuse
An alcohol and/or drug abuser in the household
An incarcerated household member
Someone who is chronically depressed, mentally ill, institutionalized, or suicidal
Mother is treated violently
One or no parents
Emotional or physical neglect
Her kan man på norsk teste sin score http://www.acestudy.org/yahoo_site_a....127143730.pdf Etter min mening er denne grovt mangelfull: den mangler det som har skjedd preverbalt (det du ikke husker), og den mangler medisinske inngrep før fylte atten år. Mobbing på skole eller i området man bor i er heller ikke med. Kanskje er det andre ting som også burde vært med, som ulykker og naturkatastrofer? Jeg har sett forskning på økt dødelighet og økt forekomst av PTSD etter store katastrofer.

.....to the idea of the effects of chronic major unrelieved stress over prolonged periods of time, and what that does in terms of flooding a person's body with high levels of circulating cortisone and related stress chemicals.
Everyone has heard that if you take cortisone, to treat rheumatoid arthritis for example, that there are major side effects. There are certainly major benefits, but also major side effects.

It doesn't matter whether you get the cortisone from a prescription bottle or from your own adrenal glands - there is a price to be paid for having unusually high, chronic levels of high circulating cortisol levels.
Often in this situation people's immune systems are suppressed. Sometimes it goes into total disarray. Bruce McEwen of the Rockefeller Institute in New York has written extensively on this subject.
There are so-called "pro-inflammatory cytokines," internally-produced chemicals that are released within one's body. These set up inflammatory reactions in the lining of very small blood vessels, causing them to close down and causing the scarification of whatever piece of organ they had been supplying.
The second big pathway deals with dysregulation. The chronic major stress pathway is responsible for a number of diseases we are beginning to get an understanding of now. Many people believe that if you are the recipient of an organ transplant, for example, you have to be on lifetime immunosuppression. Some people also know that if you are on lifetime immunosuppression, one of the side effects is an increased rate of malignancy in those individuals.
We are all producing low levels of malignant cells at all times. They are readily processed out by our immune systems and we never know the difference. Therefore, getting cancer means one of two things: either you are producing malignant cells at an accelerated rate as might occur from being a heavy smoker or from exposure to dangerous amounts of radiation, etc.; or your body's ability to recognize and process out those cells is impaired. One form of impairment comes from the damage to your immune system while taking immunosuppressant drugs after organ transplantation. Another form comes from chronic major stress over prolonged periods of time.

This would appear to be the second major pathway and it has obvious relevance to our finding of increased rates of cancer in high ACE score patients as well as the fact that we found increased rates of autoimmune diseases in high ACE score patients...
Dr. Buczynski: Which ones?
Dr. Felitti: We have a paper out where we studied twenty-one different autoimmune diseases. Without referring to the paper, I can't quote you reliably off-hand. Rheumatoid arthritis was one. Another interesting illness is the disease primary pulmonary fibrosis. Ten years ago that would have been a rock-solid example of a hardcore structural biomedical disease.

Now it is clear that at least some portion of those cases is due to the release of these so-called pro-inflammatory cytokines causing microscopic blood vessels to become inflamed, to scarify and then cause the destruction of whatever piece of lung tissue that they are supplying by converting it into scar tissue. This is known as primary pulmonary fibrosis.
The breadth of this was quite remarkable, as well as unexpected. We kept stumbling into things, some of which were fairly easy to understand and others of which were much more complex.