Ikke så meget om Florinef, men nævnt er det et par steder i bogen...:Sitat:
Opprinnelig skrevet av Vigdis
Side 34:
Because patients with spontaneous adrenocortical deficiency usually seek medical care before a complete lack of cortisol develops, replacement dosages for such patients usually total less than 35 mg (hydrocortison/red.) daily, taken as 7,5, 5, or 2,5 mg four times daily before meals and at bedtime (ac and hs). Supplementary sodium-retaining effect the form of 9-alpha-fluorohydrocortisone (9-alpha-FF marketed as Florinef), 0,1 mg daily og three times weekly, is rarely needed exept in totally adrenalectomized patients.
Side 42:
Patients who have been totally adrenalectomized or who have more severe degrees of adrenocortical deficiency can usually be satisfactorily maintained on cortisol in a dosage of 10 mg at breakfast and lunch, 5 mg at supper, and 10 mg ad bedtime. Supplementary sodium-retaining activity may be necessary, and 9-alpha-fluorohydrocortisone (9-alpha-FF, marketed as Florinef), 0,05 to 0,1 mg daily or three times weeklyis sufficient in most cases.
Side 43:
In addition to supplementary sodium-retaining activity as provided by small doses of 9-alpha-fluorohydrocortisone (9-alpha-FF, marketed as Florinef), women with severe adrenal insufficiency may require supplementary androgen to achieve optimum strength and sense of well-being. This is not surprising since their chief source of androgen is normalIy their adrenals. Unfortunately, natural adrenal androgens such as dehydroepiandrosterone (DHEA) and androstenedione are not generally available for clinical use, but some pharmacists have 5 mg capsules of DHEA. Otherwise, 5 mg linguets of methyl testosterone may be helpful to provide androgenic effects. As will be discussed later, there is evidence that DHEA is a better replacement androgen for adrenal deficiency than testosterone. Women's International Pharmacy in Madison, Wisconsin is an excellent source of physiologic dosages of dehydroepiandrosterone (DHEA).
(Oversættes så snart som muligt, bare ikke i dag. Dødtræt efter 1. omgang af tandkirurgi.)
Kilde:Sitat:
Opprinnelig skrevet av Vigdis
